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However, there is a small problem with being able to achieve this through supplementation: synthetic forms are poorly bioavailable , that is, the body cannot take advantage of them in its processes, and thus the benefits of external supply are negated

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some organisms, such as the yeast Saccharomyces cerevisiae and the nematode worm Caenorhabditis elegans , are thought to have no methylated DNA at all (although, at least in yeast, there are sequences in their genomes that are homologous to those that code for the DNMT enzymes)